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Curr Opin Cell Biol. 2000 Apr;12(2):235-43.

Smads as transcriptional co-modulators.

Author information

1
Department of Anatomy and Cell Biology, University of Toronto, Toronto, M5S 1A8, Canada. liliana.attisano@utoronto.ca

Abstract

The Smad signalling pathway is critical for transmitting transforming growth factor-beta (TGF-beta) superfamily signals from the cell surface to the nucleus. In the nucleus, Smads regulate transcriptional responses by recruiting co-activators and co-repressors to a wide array of DNA-binding partners. Thus, Smads function as transcriptional co-modulators to regulate TGFbeta-dependent gene expression.

PMID:
10712925
DOI:
10.1016/s0955-0674(99)00081-2
[Indexed for MEDLINE]

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