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Curr Opin Cell Biol. 2000 Apr;12(2):204-10.

Regulation of signal transduction by endocytosis.

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Department of Cell Biology, IMM-11, The Scripps Research Institute, La Jolla, CA 92037, USA.


Endocytosis of ligand-activated receptors has generally been considered a mechanism to attenuate signaling. There is now a growing body of evidence suggesting that this process is much more sophisticated and that endocytic membrane trafficking regulates both the intensity of signaling and the co-localization of activated receptors with downstream signaling molecules.

[Indexed for MEDLINE]

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