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Curr Opin Cell Biol. 2000 Apr;12(2):217-21.

A-kinase anchoring proteins: protein kinase A and beyond.

Author information

1
Howard Hughes Medical Institute, Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA.

Abstract

Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). In the past year there have been many advances in our understanding of AKAPs, particularly in the field of the functional consequences of PKA anchoring.

PMID:
10712918
DOI:
10.1016/s0955-0674(99)00085-x
[Indexed for MEDLINE]

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