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Eur J Neurosci. 2000 Feb;12(2):563-70.

Clustering of delta glutamate receptors is regulated by the actin cytoskeleton in the dendritic spines of cultured rat Purkinje cells.

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Laboratory for Memory & Learning, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.


The interaction of neurotransmitter receptors with the cytoskeleton is an important mechanism for the targeting of receptors to the postsynaptic membrane. Using cytoskeleton-perturbing agents, it was demonstrated that delta glutamate receptors, predominantly expressed on the dendritic spines of cerebellar Purkinje cells, are anchored to the actin cytoskeleton. The number of delta glutamate receptor-immunoreactive clusters was dramatically decreased following treatment of the Purkinje cells with the actin-disrupting agents, cytochalasin D or latrunculin A, without any significant effect on the number of presynaptic contacts of the granule cell axons. The clusters disrupted by latrunculin A were re-established 24 h after removal of the drug. These results suggest that morphological changes in the actin cytoskeleton regulate the delta glutamate receptor clustering on the dendritic spines, and may affect synaptic efficacy and plasticity.

[Indexed for MEDLINE]

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