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J Pharm Biomed Anal. 2000 Jan;21(6):1093-7.

Mechanisms of metal-catalyzed oxidation of histidine to 2-oxo-histidine in peptides and proteins.

Author information

1
Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA. schoneich@hbc.ukans.edu

Abstract

The metal-catalyzed oxidation of histidine (His) to 2-oxo-histidine (2-oxo-His) represents an important pathway of protein oxidation in vivo and in vitro. In the pharmaceutical literature this pathway has received less attention. However, this fact may not necessarily represent reality as, in some cases, the analysis of His oxidation in proteins may be compromised by aggregation and precipitation of the target protein. For predicting the susceptibility of His residues in proteins it is important to understand in detail how protein sequence and conformation control the mechanisms of His oxidation to 2-oxo-His, reviewed in this paper.

PMID:
10708394
DOI:
10.1016/s0731-7085(99)00182-x
[Indexed for MEDLINE]

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