Format

Send to

Choose Destination

RETRACTED ARTICLE

See: Retraction Notice

Nat Cell Biol. 2000 Mar;2(3):173-7.

Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels.

Author information

1
Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee 37232, USA.

Abstract

A dynamic positive feedback mechanism, known as 'facilitation', augments L-type calcium-ion currents (ICa) in response to increased intracellular Ca2+ concentrations. The Ca2+-binding protein calmodulin (CaM) has been implicated in facilitation, but the single-channel signature and the signalling events underlying Ca2+/CaM-dependent facilitation are unknown. Here we show that the Ca2+/CaM-dependent protein kinase II (CaMK) is necessary and possibly sufficient for ICa facilitation. CaMK induces a channel-gating mode that is characterized by frequent, long openings of L-type Ca2+ channels. We conclude that CaMK-mediated phosphorylation is an essential signalling event in triggering Ca2+/CaM-dependent ICa facilitation.

Comment in

PMID:
10707089
DOI:
10.1038/35004052
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center