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J Pharm Sci. 2000 Mar;89(3):297-310.

Lymphatic transport of proteins after subcutaneous administration.

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Department of Pharmaceutics, Victorian College of Pharmacy Monash University, 381 Royal Parade, Parkville, Victoria, 3052, Australia.


This mini-review summarizes the relevant literature regarding the lymphatic transport of proteins after subcutaneous administration. A review of the physiology of the lymphatics and inherent anatomical differences between blood and lymph capillaries is presented followed by a brief overview of the general characteristics of protein absorption and bioavailability following S.C. injection. A description of factors known to directly affect the lymphatic uptake of macromolecules follows and is supported by representative data from this laboratory. A brief perspective on the importance of lymphatic uptake and transport in understanding the biopharmaceutical properties of protein drugs and potentially targeting the lymphatics is presented.

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