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Growth Factors. 2000;17(3):155-66.

Early events in M-CSF receptor signaling.

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  • 1Universit√© C. Bernard Lyon I, Centre de Genetique Moleculaire et Cellulaire, UMR CNRS 5534, Villeurbanne, France.


The M-CSF receptor (M-CSFR) is expressed in monocytes-macrophages and their progenitors, and drives growth and development of this blood cell lineage. The M-CSFR is a member of a small family of growth factor receptors exhibiting related structures but distinct tissue-specific functions. This review discusses the early molecular events in the M-CSF signaling mechanisms, positive signals, negative signals, the possible organization of individual signaling pathways, and the problem of achieving specificity in the signal transduction mechanism.

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