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Genesis. 2000 Mar;26(3):189-97.

Pc-G/trx-G and the SWI/SNF connection: developmental gene regulation through chromatin remodeling.

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Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.


Pc-G and trx-G genes are responsible for maintenance of transcriptional regulation and provide a cellular memory mechanism throughout development. Studies in fly, yeast, mouse, and human have implicated modulation of higher-order chromatin structure as an important component in this process. Specifically, connections between SWI/SNF complexes and trx-G genes have provided a mechanistic link between chromatin remodeling and transcriptional regulation. Here we discuss recent genetic and biochemical data that has shed light on the molecular mechanisms and pathways associated with Pc-G and trx-G function in developmental processes such as cell cycle control and hematopoiesis. genesis 26:189-197, 2000.

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