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Respiration. 2000;67(1):36-40.

Co-expression of vascular endothelial growth factor and its receptor flt-1 in malignant pleural mesothelioma.

Author information

1
Institute of Pathology, and German Mesothelioma Registry, University Hospital Bergmannsheil, Ruhr University Bochum, Germany.

Abstract

BACKGROUND:

Vascular endothelial growth factor (VEGF) is a potent angiogenic protein with a selective mitogenic effect on endothelial cells known to be involved in many normal and pathological processes. Coexpression of VEGF and its receptor flt-1 has been reported in different types of malignant tumors.

OBJECTIVE:

In the present study we investigated the expression of VEGF and flt-1 in 90 cases of diffuse malignant pleural mesotheliomas.

METHODS:

VEGF and flt-1 expression was analyzed by immunohistochemistry and non-radioactive in situ hybridization.

RESULTS:

VEGF expression was visualized immunohistochemically in tumor cells. flt-1 expression correlated with histological differentiation (p < 0.013). Furthermore, expression of flt-1 was detected in tumor cells, macrophages and microvessels adjacent to tumor cells. VEGF and flt-1 expression were confirmed by in situ hybridization.

CONCLUSION:

There was a statistically significant correlation between VEGF and flt-1 expression (p < 0.001). The observed coexpression of VEGF and flt-1 possibly suggests a potential autocrine loop for malignant pleural mesothelioma cells.

PMID:
10705260
DOI:
10.1159/000029460
[Indexed for MEDLINE]

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