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Mech Dev. 2000 Mar 1;91(1-2):227-35.

Regulation of early expression of Dlx3, a Xenopus anti-neural factor, by beta-catenin signaling.

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Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA.


The ectoderm of the pre-gastrula Xenopus embryo has previously been shown to be at least partially patterned along the dorsal-ventral axis. The early expression of the anti-neural homeodomain gene Dlx3 is localized to the ventral ectoderm by a mechanism that occurs prior to gastrulation and is independent of the Spemann organizer. The repression of Dlx3 is mediated by signaling though beta-catenin, but is probably not dependent on the induction of the Xnr3 or chordin genes by beta-catenin. We propose a model in which this early regulation of Dlx3 accounts for the pro-neural bias of dorsal ectoderm.

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