Format

Send to

Choose Destination
Mech Dev. 2000 Mar 1;91(1-2):227-35.

Regulation of early expression of Dlx3, a Xenopus anti-neural factor, by beta-catenin signaling.

Author information

1
Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA.

Abstract

The ectoderm of the pre-gastrula Xenopus embryo has previously been shown to be at least partially patterned along the dorsal-ventral axis. The early expression of the anti-neural homeodomain gene Dlx3 is localized to the ventral ectoderm by a mechanism that occurs prior to gastrulation and is independent of the Spemann organizer. The repression of Dlx3 is mediated by signaling though beta-catenin, but is probably not dependent on the induction of the Xnr3 or chordin genes by beta-catenin. We propose a model in which this early regulation of Dlx3 accounts for the pro-neural bias of dorsal ectoderm.

PMID:
10704847
DOI:
10.1016/s0925-4773(99)00303-2
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center