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Mech Dev. 2000 Mar 1;91(1-2):143-52.

The role of cadherins during primordial germ cell migration and early gonad formation in the mouse.

Author information

1
Department of Pediatrics, University of Minnesota, Minneapolis, USA.

Abstract

Primordial germ cells (PGCs) are the founder cells of the gametes. In mammals, PGCs migrate from the hindgut to the genital ridges, where they coalesce with each other and with somatic cells to form the primary sex cords. We show here that, in both sexes, PGCs express P- and E-cadherins during and after migration, and N-cadherin at post-migratory stages. E-Cadherin is not expressed by PGCs whilst in the hindgut, but is upregulated as they leave. Blocking antibodies against E-, but not P-cadherin cause defective PGC-PGC coalescence, and in some cases, ectopic PGCs.

PMID:
10704839
DOI:
10.1016/s0925-4773(99)00287-7
[Indexed for MEDLINE]
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