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Curr Biol. 2000 Feb 24;10(4):R137-40.

Gene silencing: shrinking the black box of RNAi.

Author information

1
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA. hunter@mcb.harvard.edu.

Abstract

The mysterious mechanism whereby the mere presence of double-stranded RNA can inactivate specific genes is yielding its secrets. Recent results identifying cellular components required for RNAi in Caenorhabditis elegans indicate that the mechanism is conserved, ancient and may provide a defense against selfish DNA.

PMID:
10704407
DOI:
10.1016/s0960-9822(00)00325-0
[Indexed for MEDLINE]
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