Format

Send to

Choose Destination
Mediators Inflamm. 1999;8(4-5):205-9.

Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets.

Author information

1
Institute of General Physiology, University of Siena, Italy.

Abstract

In a previous work we have shown that heparin, in the presence of ozone (O3), promotes a dose-dependent platelet aggregation, while after Ca2+ chelation with citrate, platelet aggregation is almost negligible. These results led us to think that aggregation may enhance the release of platelet components. We have here shown that indeed significantly higher amount of platelet-derived growth factor (PDGF), transforming growth factor beta1 (TGF-beta1) and interleukin-8 (IL-8) are released in a dose-dependent manner after ozonation of heparinised platelet-rich plasma samples. These findings may explain the enhanced healing of torpid ulcers in patients with chronic limb ischemia treated with O3 autohaemoteraphy (O3-AHT).

PMID:
10704074
PMCID:
PMC1781810
DOI:
10.1080/09629359990360
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Limited Icon for PubMed Central
Loading ...
Support Center