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Tissue Antigens. 2000 Jan;55(1):48-52.

The relative frequencies of HLA-DRB1*01 alleles in the major US populations.

Author information

1
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA.

Abstract

The frequencies of alleles in the HLA-DRB1*01 family were determined in each of five US populations from a database of 82,979 individuals. Individuals typed as DR1 (or DRB1*01) comprised between 7.6%-21.3% of the individuals in each population group. Fifty-nine DR1 individuals were randomly selected from each group and subjected to high-resolution DNA typing by polymerase chain reaction using sequence-specific oligonucleotide probes. DRB1*0101 was the most common allele in the Caucasian, Asian/Pacific Islander, and Native American groups while the DRB1*0102 allele was found in the majority of African Americans and Hispanics. DRB1*0103 was present at a similar frequency in all populations. DRB1*0104, DRB1*0105, and DRB1*0106 alleles were not observed.

PMID:
10703608
[Indexed for MEDLINE]

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