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Intervirology. 1999;42(5-6):365-72.

Human cytomegalovirus infection of immature dendritic cells and macrophages.

Author information

1
Department of Medical Virology, University of Tübingen, Tübingen, Germany. gdjahn@med.uni-tuebingen.de

Abstract

A central aspect of human cytomegalovirus (HCMV) pathogenesis is the interaction of the virus with different antigen-presenting cell (APC) types of the host. In principle, a number of various cell types have the potential of antigen presentation when MHC II expression is induced by appropriate stimuli. The most potent antigen presenters are monocytes/macrophages and dendritic cells (DCs), therefore called professional APCs. Interestingly, these cells seem to be targets of productive HCMV infection. The susceptibility of the monocyte/macrophage system has been analyzed intensively during the past decade. Investigation of the role of DCs during HCMV infection, however, has begun only recently.

PMID:
10702719
DOI:
10.1159/000053973
[Indexed for MEDLINE]

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