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J Antimicrob Chemother. 2000 Mar;45(3):371-3.

Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro.

Author information

1
Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK. f.odds@abdn.ac.uk

Abstract

Microbroth dilution tests in vitro showed the same IC(50) values for itraconazole and hydroxy-itraconazole, within a mode +/- one dilution range of experimental error, for 90% of 1481 isolates of pathogenic fungi, representing 48 genera. Some 10-15% of Candida glabrata and Trichophyton mentagrophytes isolates were more susceptible to itraconazole than hydroxy-itraconazole. Replicate tests with bioassay marker strains of Candida kefyr and Candida albicans showed no susceptibility variations outside the mode +/- one dilution range. We conclude that few fungi differ substantially in their susceptibility to itraconazole and hydroxy-itraconazole.

PMID:
10702560
DOI:
10.1093/jac/45.3.371
[Indexed for MEDLINE]

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