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J Neurosci Res. 2000 Mar 15;59(6):706-11.

Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease.

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  • 1Departments of Neurology and the Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA.


Oligodendrocyte-specific protein (OSP/claudin-11) is a four transmembrane protein concentrated in central nervous system myelin. Recent evidence has emerged suggesting that OSP/claudin-11 is involved in membrane interactions at tight junctions and with the extracellular matrix. OSP/claudin-11 seems to modulate proliferation and migration of oligodendrocytes presumably through these interactions. Furthermore, evidence is presented implicating OSP/claudin-11 as an autoantigen in the development of autoimmune demyelinating disease.

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