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RETRACTED ARTICLE

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Science. 2000 Mar 3;287(5458):1660-4.

Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein.

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1
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912-2300, USA.

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Abstract

The synergistic response of cells to the stimulation of multiple receptors has been ascribed to receptor cross talk; however, the specific molecules that mediate the resultant signal amplification have not been defined. Here a 24-kilodalton single transmembrane protein, designated calcyon, we functionally characterize that interacts with the D1 dopamine receptor. Calcyon localizes to dendritic spines of D1 receptor-expressing pyramidal cells in prefrontal cortex. These studies delineate a mechanism of Gq- and Gs-coupled heterotrimeric GTP-binding protein-coupled receptor cross talk by which D1 receptors can shift effector coupling to stimulate robust intracellular calcium (Ca2+i) release as a result of interaction with calcyon. The role of calcyon in potentiating Ca2+-dependent signaling should provide insight into the D1 receptor-modulated cognitive functions of prefrontal cortex.

PMID:
10698743
[Indexed for MEDLINE]
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