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Am J Med Sci. 2000 Feb;319(2):79-83.

Immunohistochemical localization of modified C-reactive protein antigen in normal vascular tissue.

Author information

1
Department of Otolaryngology/Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA.

Abstract

BACKGROUND:

The prototypic acute phase reactant, C-reactive protein (CRP), is a serum soluble, cyclic pentameric protein, the concentration of which increases markedly within hours of any tissue-damaging, inflammatory event. However, upon dissociation of its pentameric quaternary structure, CRP subunits undergo a spontaneous and irreversible conformational change. The resulting molecule, termed modified CRP or mCRP, has reduced aqueous solubility and a propensity to aggregate into a matrix-like lattice structure.

METHODS:

Using monoclonal antibodies, normal human tissues were immunohistochemically screened for the presence of CRP as well as mCRP antigens.

RESULTS:

Significant levels of mCRP were detected in the walls of blood vessels associated with normal human tissues. These data indicate that mCRP is a naturally occurring form of CRP and that it is a tissue-based rather than serum-based molecule.

SIGNIFICANCE:

This report describes the localization of a stable form of CRP, mCRP, in blood vessels associated with normal human tissues.

[Indexed for MEDLINE]

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