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Mol Pathol. 1999 Aug;52(4):169-73.

The adenomatous polyposis coli protein.

Author information

1
Department of Anatomy and Physiology, University of Dundee, UK. i.s.nathke@dundee.ac.uk

Abstract

Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell. First, APC is a component of the Wnt signalling pathway; second, APC may have a role in cell migration; finally, APC may regulate proliferation and apoptosis.

PMID:
10694935
PMCID:
PMC395695
DOI:
10.1136/mp.52.4.169
[Indexed for MEDLINE]
Free PMC Article

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