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Trends Biochem Sci. 2000 Mar;25(3):115-20.

The dynamin family of mechanoenzymes: pinching in new places.

Author information

1
Dept of Biochemistry and Molecular Biology, The Center for Basic Research in Digestive Diseases, Mayo Foundation, Rochester, MN 55905, USA. mcniven.mark@mayo.edu

Abstract

The large GTPase dynamin is a mechanoenzyme that mediates the liberation of nascent clathrin-coated pits from the plasma membrane during endocytosis. Recently, this enzyme has been demonstrated to comprise an extensive family of related proteins that have been implicated in a large variety of vesicle trafficking events during endocytosis, secretion and even maintenance of mitochondrial form. The potential contributions by the dynamin family to these diverse but related functions are discussed.

PMID:
10694881
DOI:
10.1016/s0968-0004(99)01538-8
[Indexed for MEDLINE]

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