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Proc Natl Acad Sci U S A. 1976 Nov;73(11):4159-63.

Heat mutagenesis in bacteriophage T4: the transversion pathway.

Abstract

Heat induces transversions (as well as transitions) at G-C base pairs in bacteriophage T4. The target base for transversions is guanine,which is converted to a product which is sometimes replicated and transcribed as a pyrimidine.A model for this process is proposed in which the deoxyguanosine glycosidic bond migrates from N9 to N2: the resulting deoxyneoguanosine may pair with normal guanine to produce G-C leads to C-G transversions.

PMID:
1069305
PMCID:
PMC431367
DOI:
10.1073/pnas.73.11.4159
[Indexed for MEDLINE]
Free PMC Article

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