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Annu Rev Genet. 1999;33:29-55.

Fas ligand-induced apoptosis.

Author information

1
Department of Genetics, Osaka Medical School, Japan. nagata@genetic.med.osaka-u.ac.jp

Abstract

The immune response is regulated not only by cell proliferation and differentiation, but also by programmed cell death, or apoptosis. In response to various stimuli, death factors bind to their respective receptors and activate the apoptotic death program in target cells. A cascade of specific proteases termed caspases mediates the apoptotic process. The activated caspases cleave various cellular components, a process that leads to morphological changes of the cells and nuclei, as well as to degradation of the chromosomal DNA. Loss-of-function mutations in the signaling molecules involved in apoptosis cause hyper-proliferation of cells in mouse and human. In contrast, exaggeration of this death cascade causes the destruction of various tissues.

PMID:
10690403
DOI:
10.1146/annurev.genet.33.1.29
[Indexed for MEDLINE]

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