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Trends Pharmacol Sci. 2000 Mar;21(3):93-8.

Development of pharmacological agents for targeting neurotrophins and their receptors.

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Departments of Pharmacology and Therapeutics, Oncology and the Cancer Center, McGill University, 3655 Drummond St. #1320, Montréal, QC, Canada H3G 1Y6.


Neurotrophins comprise a family of protein growth factors that control the survival, growth, and/or differentiation of neurons and several other cell populations derived from the neuroectoderm. Neurotrophins and their receptors are important targets for the therapy of human disease, with potential applications ranging from the treatment of chronic or acute neurodegeneration to pain and cancer. Neurotrophins have been used clinically but are poor pharmacological agents. Consequently, approaches to develop pharmacological agents that target neurotrophins, their receptors or neurotrophin signaling pathways have been attempted.

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