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Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9.

The structure of a stable intermediate in the A <--> B DNA helix transition.

Author information

1
Molecular Biology Institute, University of California, Los Angeles, CA 90095-1570, USA.

Abstract

The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition.

PMID:
10688897
PMCID:
PMC15749
DOI:
10.1073/pnas.040571197
[Indexed for MEDLINE]
Free PMC Article

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