Format

Send to

Choose Destination
Fertil Steril. 2000 Feb;73(2):287-91.

Effects of clomiphene citrate on the endometrium of regularly cycling women.

Author information

1
Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. trcwsr@md2.md.chula.ac.th

Abstract

OBJECTIVE:

To study the effects of clomiphene citrate (CC) on the endometrium of regularly cycling women.

DESIGN:

Prospective, controlled study.

SETTING:

Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

PATIENT(S):

Thirty healthy, regularly cycling, female volunteers.

INTERVENTION(S):

All volunteers were studied for two consecutive cycles, one control cycle and one CC-treated cycle. Clomiphene citrate (100 mg/d) was given on days 3-7 of the CC-treated cycles. Ultrasonography was performed daily to assess ovulation. Ultrasonography and endometrial biopsy were performed, and blood samples were obtained for determination of E2 and progesterone levels 7 days after ovulation in both the control and CC-treated cycles.

MAIN OUTCOME MEASURE(S):

Histologic dating, morphometric analysis, and ultrasonographic appearance and thickness of the endometrium.

RESULT(S):

Histologic dating and ultrasonographic appearance and thickness of the endometrium were similar in the control and CC-treated cycles, but morphometric parameters were different. The number of glands per square millimeter and the mean diameter of the glands were lower in the CC-treated cycles than in the control cycles, but the number of vacuolated cells per 1,000 glandular cells was higher.

CONCLUSION(S):

Clomiphene citrate has effects on the endometrium of regularly cycling women, as demonstrated by a reduction in glandular density and an increase in the number of vacuolated cells.

PMID:
10685531
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center