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Med J Aust. 2000 Jan 3;172(1):16-8.

Concordance between use of proton pump inhibitors and prescribing guidelines.

Author information

1
Department of Clinical Pharmacology, Princess Alexandra Hospital, Brisbane, QLD. pillansp@health.qld.gov.au

Abstract

OBJECTIVE:

To determine (i) the relationship between prescriptions for proton pump inhibitors (PPIs) and upper gastrointestinal conditions, and (ii) compliance with Pharmaceutical Benefits Scheme (PBS) prescribing guidelines for PPIs.

DESIGN:

Drug utilisation evaluation.

SETTING:

800-bed metropolitan teaching hospital.

PARTICIPANTS:

253 patients dispensed PPIs from the hospital pharmacy over five consecutive weeks (11 January to 15 February 1999).

MAIN OUTCOME MEASURES:

Recorded gastrointestinal conditions; previous trial of H2-antagonist therapy; compliance with PBS criteria for prescribing PPIs.

RESULTS:

Seventy patients (27.7%) had no appropriate upper gastrointestinal tract investigations, and 62 patients (24%) did not receive an adequate trial of H2-antagonist therapy before the commencement of a PPI. The major indications for use of PPIs in investigated patients were gastro-oesophageal reflux in 99 (54%) and peptic ulcer disease in 30 (16.4%). In only 57 patients (22.5%) did PPI prescriptions comply with PBS prescribing guidelines. Clinical indications that failed to meet prescribing criteria included milder forms of gastro-oesophageal reflux, gastritis/duodenitis, and non-specific dyspepsia with normal endoscopy results.

CONCLUSION:

Drug utilisation data indicate widespread use of PPIs outside current prescribing guidelines. Many patients have not had relevant investigations and/or an adequate trial of H2-antagonist therapy. These findings explain the considerable hospital expenditure on PPIs.

PMID:
10682010
[Indexed for MEDLINE]

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