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Antimicrob Agents Chemother. 2000 Mar;44(3):794-7.

Delavirdine susceptibilities and associated reverse transcriptase mutations in human immunodeficiency virus type 1 isolates from patients in a phase I/II trial of delavirdine monotherapy (ACTG 260).

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1
University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. Lisa_Demeter@urmc.rochester.edu

Abstract

The development of human immunodeficiency virus type 1 resistance to delavirdine (DLV) was studied in subjects receiving DLV monotherapy. Phenotypic resistance developed in 28 of 30 subjects within 8 weeks. K103N and Y181C, which confer nonnucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance, were the predominant reverse transcriptase mutations. P236L, which confers DLV resistance but hypersensitivity to other NNRTIs, developed in <10% of isolates.

PMID:
10681363
PMCID:
PMC89771
[Indexed for MEDLINE]
Free PMC Article

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