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Cancer Causes Control. 2000 Jan;11(1):1-8.

Western diet, family history of colorectal cancer, NAT2, GSTM-1 and risk of colon cancer.

Author information

1
Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, USA.

Abstract

OBJECTIVE:

In this study we examine the combined effects of Western diet, age at diagnosis, and genetic susceptibility.

METHODS:

We use data collected as part of an incident case-control study of colon cancer. Family history of colorectal cancer, N-acetyltransferase (NAT2), and glutathione-S-transferase (GSTM-1) are studied with Western diet and age at diagnosis.

RESULTS:

A significant interaction between age at time of diagnosis, Western dietary pattern, and family history of colorectal cancer (p for interaction = 0.03) was detected. Those with a family history of colorectal cancer who ate a predominantly Western diet were at increased risk of colon cancer (OR 14.0, 95% CI 3.9-50.1 for < or = 55 years; OR 7.7, 95% CI 2.0-29.1 for 56-66 years; OR 1.6, 95% CI 0.8-3.2 for > or = 67 years) compared to those without a family history of colorectal cancer and low levels of a Western diet. Associations with the Western diet were stronger than individual components of the dietary pattern. Neither NAT2 nor GSTM-1 showed significant interaction with Western diet.

CONCLUSION:

The extent to which diet comprising a Western dietary pattern influences risk of colon cancer is dependent on age. This dietary pattern also appears to modulate the colon cancer risk associated with a family history of colon cancer.

PMID:
10680724
DOI:
10.1023/a:1008913619957
[Indexed for MEDLINE]

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