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Curr Opin Neurobiol. 2000 Feb;10(1):125-31.

Development of neuron-neuron synapses.

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Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114,USA.


Our understanding of neuronal synapse development has advanced in recent years. The development of glycinergic synapses appears to depend on gephyrin and glycine receptor activity. Molecular characterization of the structure and development of glutamatergic synapses is in progress, but the underlying mechanisms remain unclear. Activity-dependent mechanisms and specific molecules that regulate the morphological development of dendritic spines have recently been identified.

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