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Curr Opin Microbiol. 2000 Feb;3(1):54-9.

Cellular routes of invasion by enteropathogens.

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1
Departments of Medicine, Pathology and Microbiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

Abstract

The cellular pathways of infection utilized by pathogenic enteric bacteria have important implications for their clinical manifestations. Yersinia reaches Peyer's patches via M cells and uses plasmid-encoded factors to resist phagocytic cells. Shigella also translocates via M cells and incapacitates phagocytes, but subsequently re-enters the epithelium basolaterally to elicit an acute inflammatory response. Salmonella has recently been shown to both colonize Peyer's patches via M cells and independently disseminate to extraintestinal sites via CD18-expressing phagocytes. M cell-mediated entry can lead to gastroenteritis and mucosal antibody production, while systemic dissemination can result in septicemia and elicitation of systemic immune responses.

PMID:
10679413
[Indexed for MEDLINE]

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