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Curr Opin Immunol. 2000 Feb;12(1):13-9.

Toll signaling pathways in the innate immune response.

Author information

1
Molecular Biology Program, Sloan-Kettering Institute, New York, NY 10021, USA. k-anderson@ski.mskcc.org

Abstract

The Toll signaling pathway, which is required for the establishment of the dorsal-ventral axis in Drosophila embryos, plays an important role in the response of larval and adult Drosophila to microbial infections. Recent genetic evidence has shown that a mammalian Toll-like receptor, mouse Tlr4, is the signal transducing receptor activated by bacterial lipopolysaccharide. Thus, Toll-like receptors appear to detect a variety of microbial components and to trigger a defensive reaction in both Drosophila and mammals. Genetic data from both Drosophila and mice have defined components required for activation of Toll-like receptors and for the downstream pathways activated by the Toll-like receptors.

PMID:
10679407
DOI:
10.1016/s0952-7915(99)00045-x
[Indexed for MEDLINE]

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