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Curr Opin Genet Dev. 2000 Feb;10(1):120-7.

Extrinsic regulators of epithelial tumor progression: metalloproteinases.

Author information

1
Hormone Research Institute, University of California, 1090 HSW Box 0534, San Francisco, California 94143, USA. bergers@cgl.ucsf.edu.

Abstract

Extracellular metal-dependent proteinases regulate cell behavior by remodeling stromal and cell surface proteins, thereby influencing cell recruitment, cell shape, motility, proliferation, survival, genomic (in)stability, and differentiation. In recent years, the importance of proteinase-induced signaling has been underscored by evidence that altered regulation of cell-extracellular matrix and cell-cell interactions by proteinases can contribute, in a causal manner, to neoplastic progression.

PMID:
10679388
[Indexed for MEDLINE]
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