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Curr Opin Genet Dev. 2000 Feb;10(1):32-8.

RecQ family helicases: roles in cancer and aging.

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Imperial Cancer Research Fund Laboratories, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.


The RecQ family of DNA helicases includes at least three members in humans that are defective in genetic disorders associated with cancer predisposition and/or premature aging. Recent studies have shed light on the roles of RecQ helicases in suppressing 'promiscuous' genetic recombination and in ensuring accurate chromosome segregation. In particular, the biochemical properties of several family members have been characterised and functional interactions with other nuclear proteins have been defined.

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