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Curr Opin Genet Dev. 2000 Feb;10(1):94-9.

The ARF/p53 pathway.

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1
Department of Tumor Cell Biology, Howard Hughes Medical Institute, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. sherr@stjude.org.

Abstract

The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.

PMID:
10679383
[Indexed for MEDLINE]
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