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Curr Opin Chem Biol. 2000 Feb;4(1):16-21.

New approaches for cell-specific targeting: identification of cell-selective peptides from combinatorial libraries.

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Department of Internal Medicine, Center for Biomedical Inventions, University of Texas, Southwestern Medical Center, Dallas, TX 75390-8573, USA.


Peptides that recognize specific cell types promise to be valuable tools both in research and clinical applications. Cell-specific peptides can be useful as drug delivery vehicles, diagnostic agents, affinity reagents for cell purification, gene therapy delivery agents, and research tools to probe the nature of a cell's surface. Recently, cell-specific targeting-peptides have been identified by phage-display selections against purified cell-surface markers, whole cells in tissue culture, and even tissues within live animals. These methods for identifying cell-targeting peptides will certainly increase the tools available to the scientist for cell-specific targeting.

[Indexed for MEDLINE]

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