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Curr Opin Cell Biol. 2000 Feb;12(1):104-12.

Actin machinery: pushing the envelope.

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Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706, USA.


The reconstitution of microbial rocketing motility in vitro with purified proteins has recently established definitively that no myosin motor is required for protrusion. Instead, actin polymerization, in conjunction with a small number of proteins, is sufficient. A dendritic pattern of nucleation controlled by the Arp2/3 complex provides an efficient pushing force for lamellipodial motility.

[Indexed for MEDLINE]

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