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Curr Opin Cell Biol. 2000 Feb;12(1):91-6.

How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures.

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Department of Cellular and Molecular Pharmacology, University of California Medical School, San Francisco, CA 94129, USA. dyche@itsa.


In most cells, the structure of the actin cytoskeleton is regulated by Rho-family G proteins. Recent work has outlined a highly conserved signaling pathway from G protein activation to actin assembly. The key downstream components are WASP family proteins - adaptor molecules that bind multiple signaling and cytoskeletal proteins - and the Arp2/3 complex - a multi-functional protein complex that nucleates and crosslinks actin filaments.

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