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Curr Opin Biotechnol. 2000 Feb;11(1):47-53.

High-throughput and ultra-high-throughput screening: solution- and cell-based approaches.

Author information

1
Caliper Technologies Corporation, CA 94043, USA. steve. sundberg@calipertech.com

Abstract

The trend towards assay miniaturization for high-throughput and ultra-high-throughput screening continues to spur development of homogeneous, fluorescence-based assays in higher density, smaller volume microplate formats. Recently, first-generation microfluidic devices have been designed for performing continuous-flow biochemical and cell-based assays. These devices provide orders-of-magnitude reduction in reagent consumption, and offer the potential for implementing high-throughput screening in formats that integrate up-front compound handling with unique assay functionality.

PMID:
10679349
[Indexed for MEDLINE]

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