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Trends Neurosci. 2000 Mar;23(3):105-13.

Unveiling synaptic plasticity: a new graphical and analytical approach.

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Division of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia.


Short-term synaptic plasticity has a key role in information processing in the CNS, whereas memories can be formed through long-lasting changes in synaptic strength. Despite the importance of these phenomena, it remains difficult to determine whether a synaptic modulation is expressed at a presynaptic or postsynaptic site. This article describes a new approach that, in its simplest form, can identify the site of expression by direct graphical means. A more-sophisticated form of the technique can quantify functional synaptic properties and determine which of these properties is altered following a modulation of synaptic strength.

[Indexed for MEDLINE]

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