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Gene. 2000 Jan 11;241(2):255-8.

cDNA cloning of run, a Caenorhabditis elegans Runt domain encoding gene.

Author information

1
Department of Biochemistry, School of Medicine, Chungbuk National University, Chungju, South Korea. scbae@med.chungbuk.ac.kr

Abstract

PEBP2/CBF is a heterodimeric transcription factor composed of alpha and beta subunits. The essential roles of mammalian PEBP2alpha genes, PEBP2aA/CBFA1 and PEBP2alphaB/CBFA2 in osteogenesis and hematopoiesis have been well documented. The PEBP2alpha proteins contain a 128 amino acid (aa) region which is highly homologous to Drosophila melanogaster runt and lozenge. The evolutionarily conserved region has been named the Runt domain. In this study, we isolated a cDNA encoding the Caenorhabditis elegans homolog of mammalian PEBP2alpha. The cDNA encodes a 301-aa protein with a highly conserved Runt domain. In addition, a IWRPF five aa motif is present at the C-terminal end.

PMID:
10675037
DOI:
10.1016/s0378-1119(99)00488-6
[Indexed for MEDLINE]

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