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Pediatr Res. 2000 Feb;47(2):246-9.

IL4 and IL4Ralpha genes are not linked or associated with type 1 diabetes.

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1
Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville 32610, USA.

Abstract

Previous studies have shown the immunoregulatory functions IL-4 in type 1 diabetes mellitus. Therefore, the genes involved in the IL-4 regulatory pathway are candidates for diabetes susceptibility genes. Here we have evaluated IL4 and the alpha subunit of the IL-4 receptor (IL4Ralpha) genes using the affected sibpair (ASP) and transmission/disequilibrium test (TDT). We analyzed 309 diabetic families from the United States and 87 families from various European countries. There was no evidence that either of these two genes are linked or associated with type 1 diabetes. Means by which IL-4 directed signals could indirectly alter diabetes susceptibility are proposed.

[Indexed for MEDLINE]

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