The manifold of vitamin B6 dependent enzymes

Structure. 2000 Jan 15;8(1):R1-6. doi: 10.1016/s0969-2126(00)00085-x.

Abstract

Pyridoxal-5'-phosphate (vitamin B6) binding enzymes form a large superfamily that contains at least five different folds. The availability of an increasing number of known three-dimensional structures for members of this superfamily has allowed a detailed structural classification. Most progress has been made with the fold type I or aspartate aminotransferase family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alanine Racemase / chemistry
  • Alanine Racemase / metabolism
  • Alanine Transaminase / chemistry
  • Alanine Transaminase / metabolism
  • Animals
  • Aspartate Aminotransferases / chemistry
  • Aspartate Aminotransferases / metabolism
  • D-Alanine Transaminase
  • Enzymes / chemistry*
  • Enzymes / metabolism*
  • Humans
  • Phosphorylases / chemistry
  • Phosphorylases / metabolism
  • Protein Folding
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Pyridoxine / metabolism*
  • Tryptophan Synthase / chemistry
  • Tryptophan Synthase / metabolism

Substances

  • Enzymes
  • Phosphorylases
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • D-Alanine Transaminase
  • Tryptophan Synthase
  • Alanine Racemase
  • Pyridoxine