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Bioorg Med Chem Lett. 2000 Jan 17;10(2):179-82.

RGD mimetics containing a central hydantoin scaffold: alpkha(v)beta3 vs alpha(IIb)beta3 selectivity requirements.

Author information

1
Hoechst Marion Roussel Deutschland GmhH, Frankfurt, Germany. anusch.peyman@hmrag.com

Abstract

The synthesis of a series of RGD mimetic alpha(v)beta3 antagonists containing a hydantoin scaffold is shown. The results demonstrate some of the structural requirements for the design of selective alpha(v)beta3 antagonists (vs alpha(IIb)beta3) in terms of the Arg-mimetic, the distance between N- and C-terminus and the lipophilic side chain.

PMID:
10673106
DOI:
10.1016/s0960-894x(99)00661-7
[Indexed for MEDLINE]

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