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Bioorg Med Chem Lett. 2000 Jan 17;10(2):175-8.

Synthesis and evaluation of furo[3,4-d]pyrimidinones as selective alpha1a-adrenergic receptor antagonists.

Author information

1
Department of Chemistry, Synaptic Pharmaceutical Corporation, Paramus, NJ 07652, USA.

Abstract

Furo[3,4-d]pyrimidinones were found to be metabolites of dihydropyrimidinones such as 1a-b that are subtype-selective antagonists of the alpha1a-adrenergic receptor. A versatile synthesis that provides access to furo[3,4-d]pyrimidinones in high yield and in enantiomerically pure forms is described along with structure-activity relationships in the series.

PMID:
10673105
DOI:
10.1016/s0960-894x(99)00653-8
[Indexed for MEDLINE]

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