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Biochim Biophys Acta. 1999 Dec 23;1489(2-3):452-6.

Cloning, expression and characterization of a novel human Ras-related protein that is regulated by glucocorticoid hormone.

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Department of Cell Biology and the Cell Adhesion and Matrix Research Center, University of Alabama at Birmingham, 35294-0019, USA.


Ras proteins are a family of guanine nucleotide (GDP and GTP)-binding proteins that play central roles in essential signal transduction pathways. We have isolated in a yeast two-hybrid screen a human cDNA encoding a new protein that is highly homologous (98% identical at the protein level) to mouse DexRas1, a member of the Ras superfamily. The human DexRas1 is expressed in a variety of tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with the strongest expression in the heart. Using human fibrosarcoma HT-1080 cells as a model system, we show that the expression of human DexRas1 is stimulated by dexamethasone, suggesting a role of human DexRas1 in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions.

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