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Am J Psychiatry. 2000 Feb;157(2):281-3.

MRI assessment of children with obsessive-compulsive disorder or tics associated with streptococcal infection.

Author information

1
Child Psychiatry and Pediatrics and Developmental Neuropsychiatry Branch of NIMH, Bethesda, MD 20892-1600, USA. jgiedd@helix.nih.gov

Abstract

OBJECTIVE:

The authors assessed selective basal ganglia involvement in a subgroup of children with obsessive-compulsive disorder (OCD) and/or tics believed to be associated with streptococcal infection.

METHOD:

Using computer-assisted morphometric techniques, they analyzed the cerebral magnetic resonance images of 34 children with presumed streptococcus-associated OCD and/or tics and 82 healthy comparison children who were matched for age and sex.

RESULTS:

The average sizes of the caudate, putamen, and globus pallidus, but not of the thalamus or total cerebrum, were significantly greater in the group of children with streptococcus-associated OCD and/or tics than in the healthy children. The differences were similar to those found previously for subjects with Sydenham's chorea compared with normal subjects.

CONCLUSIONS:

These results support the hypothesis that there is a distinct subgroup of subjects with OCD and/or tics who have enlarged basal ganglia. These findings are consistent with the hypothesis of an autoimmune response to streptococcal infection.

PMID:
10671403
DOI:
10.1176/appi.ajp.157.2.281
[Indexed for MEDLINE]

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