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Neurosci Lett. 2000 Jan 21;279(1):1-4.

Migraine in childhood--are periodically occurring migraine attacks related to dynamic changes of cortical information processing?

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Institute of Medical Psychology, Center of Nervous Diseases, University of Kiel, Germany.


Amplitudes and habituation of contingent negative variation (CNV) were analyzed in relation to spontaneously occurring migraine attacks in ten children suffering from migraine without aura. Recording took place during feedback training and instrumental conditioning of slow brain potentials. Both the amplitude of the early CNV component and its habituation deficit increase during the 5 days prior to a migraine attack, with maximum abnormalities the day before the ictal episode. Abrupt reduction of the amplitude and normalization of the CNV habituation were observed during the attack. This study provides evidence for neurophysiological periodicity in young migraineurs and emphasizes that the time relative to the migraine attacks must be considered in studies of juvenile migraine during the headache-free period.

[Indexed for MEDLINE]

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