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Invest Ophthalmol Vis Sci. 2000 Feb;41(2):546-51.

Differential expression of cadherin adhesion receptors in neural retina of the postnatal mouse.

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1
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Shogoin, Japan.

Abstract

PURPOSE:

To determine the expression pattern of multiple subtypes of cadherin adhesion receptor in postnatal mouse neural retina.

METHODS:

The expression of N-cadherin, R-cadherin, cadherin-6, cadherin-8, and cadherin-11 in retinas at postnatal days 0 to 42 was analyzed by in situ hybridization of mRNA as well as by immunohistochemistry.

RESULTS:

Each cadherin was expressed by different cell populations of the retina, and the following expression patterns were established by postnatal day 14: in the ganglion cell layer, all these molecules were expressed, but each occurred only in a subset of the cells. Likewise, in the inner nuclear layer, R-cadherin and cadherin-6 and -8 were expressed by a restricted population of amacrine cells, and cadherin-8 also by a subpopulation of bipolar cells. All horizontal cells expressed R-cadherin, and Muller cells expressed N-cadherin and cadherin-11. Proteins of R-cadherin and cadherin-6 were concentrated in neuropil layers.

CONCLUSIONS:

The pattern of differential expression of the five cadherins supports the idea that these molecules may play a role in selective cell interactions within the heterogeneous cell pool of the neural retina.

PMID:
10670487
[Indexed for MEDLINE]
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